Preclinical, clinical and validation studies of technologies for the prevention, diagnosis and treatment of tropical and infectious diseases (DTIs)

Studies on the process of evaluating the safety, efficacy, effectiveness and cost-effectiveness of technologies for the therapy, prevention and diagnosis of DTIs. It includes prospection and characterization studies of molecules of interest in the treatment of DTIs; in vitro, ex vivo, in silico and laboratory animal assays of biologically active molecules; clinical trials for the evaluation of the safety and efficacy of drugs and non-pharmacological interventions for the treatment of ILDs; studies on the pharmacodynamics, pharmacokinetics and pharmacogenetics of drugs used in the treatment of ILDs; clinical trials to evaluate the safety and efficacy of vaccines and other forms of prevention of ITDs; pharmacovigilance studies of medicines and other health products; studies to validate the accuracy and reproducibility of diagnostic tests; validation studies of educational technologies, including computational ones, for prevention and adherence to the diagnosis and treatment of ILDs; studies on the implementation of therapeutic, prevention and diagnostic interventions for ILDs; studies of the cost and cost-effectiveness of technologies for the therapy, prevention and diagnosis of DTIs; studies of education and scientific dissemination for health promotion in the control of ITDs.

 

Studies on the burden, prognosis, and identification of genetic, immunological, social, cultural, and economic markers of tropical and infectious diseases (DTIs)

Descriptive or analytical, cross-sectional or longitudinal studies, with quantitative or qualitative methodology aimed at measuring the frequency of DTIs, their outcomes and determinants. Includes studies on the prevalence and incidence of DTIs; studies to identify risk factors for DTI; studies to describe clinical, laboratory, and functional outcomes and identify prognostic factors for these outcomes; evaluation of quality of life in patients with ITD; studies of the genetic and immunological profile predictor or prognosis in DTIs; qualitative or mixed studies for the characterization of subjective, social, cultural and economic determinants in DTIs; studies on cause of death in DTIs; ecological studies on the influence of socioeconomic, historical, and cultural indicators on the burden of DTIs; application of computational technologies, including artificial intelligence, in the analysis of DTI data.

 

Studies on the interaction between the different components of tropical and infectious disease (DTI) cycles, including humans, animals, pathogens, and the environment.

Transdisciplinary, integrated, and unifying studies that aim to sustainably balance and optimize the health of people, animals, and ecosystems, with a special interest in the Amazon biome. It includes studies on the ecology, genetics, diversity, and other aspects of the biology of disease vectors, venomous animals, and other animals of medical interest; studies on the genetics, morphology, biochemistry and other aspects of the biology of pathogens; studies on the pathogen-vector relationship; studies on the relationship between pathogens and human or between pathogens and animal models; in vitro, ex vivo and in vivo studies on the interaction between toxins and other products of metabolism in animals of health interest; studies on the mechanisms of pathogenesis of DTIs; studies from the perspective of One Health (contemplating human, animal and environmental health), involving the interaction of man with the biotic and abiotic components relevant to the cycles of DTIs; studies on the impact of environmental and climate change on the burden of DTIs.